Successful pregnancies and healthy live births using frozen-thawed sperm retrieved by a new modified Hotchkiss procedure in males with retrograde ejaculation: first case series

Basic and Clinical Andrology, 2015 · DOI: 10.1186/s12610-015-0021-4 · Published: May 4, 2015

Simple Explanation

This study focuses on couples where the male partner has retrograde ejaculation (RE) that doesn't respond to medication. Retrograde ejaculation is when semen goes backward into the bladder instead of out of the penis during ejaculation. The researchers used a modified Hotchkiss technique (MHT) to retrieve sperm from the bladder, then froze the sperm for later use in assisted reproductive technology (ART). The study found that this method led to successful pregnancies and live births, suggesting it's an effective option for couples facing this type of infertility.

Study Duration

2004-2014 (10 years)

Participants

10 couples with males having refractory retrograde ejaculation

Evidence Level

Retrospective, single-center study

Key Findings

1
Nine clinical pregnancies were achieved in six couples out of 26 ICSI cycles using frozen-thawed sperm retrieved by the modified Hotchkiss technique.
2
The average live birth rate per transfer was 28 %.
3
60% of couples treated with the modified Hotchkiss technique obtained at least one clinical pregnancy.

Research Summary

The study evaluated a modified Hotchkiss technique (MHT) combined with sperm cryopreservation for couples with retrograde ejaculation (RE) refractory to medical treatment. The results showed successful pregnancy and live birth rates using ICSI with frozen-thawed sperm retrieved from the bladder using the new MHT. The authors conclude that this technique provides an efficient and easier management option for couples with refractory RE.

Practical Implications

Improved Management of Retrograde Ejaculation

The modified Hotchkiss technique combined with sperm cryopreservation offers a simple and efficient approach for managing infertility in couples where the male partner has retrograde ejaculation.

Facilitates ART Scheduling

Sperm cryopreservation allows for asynchronous management, removing the time-sensitive requirement of fresh sperm retrieval on the day of ART.

Reduces Catheterization Risks

The technique minimizes the need for repeated bladder catheterizations, reducing the risks of stricture or infection, particularly beneficial for diabetic patients.

Study Limitations

1
Single-center study
2
Retrospective design
3
Implied use in IVF, which is more invasive for the female partner than IUI treatment.

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