Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion

Following spinal cord injury, axons do not regenerate effectively due to an inhibitory microenvironment. This study investigates the combined effects of olomoucine and GDAsBMP in rats with spinal cord contusion to improve nerve regeneration. Olomoucine inhibits glial proliferation and scar formation after spinal cord injury, potentially improving the injury microenvironment. GDAsBMP, when transplanted into the injured spinal cord, can fill the injury cavity and inhibit glial scarring. The study found that the combined use of olomoucine and GDAsBMP creates a better environment for nerve regeneration compared to either treatment alone, contributing to spinal cord repair after injury.

• 1
  Olomoucine effectively inhibited astrocyte proliferation and the formation of scar tissue at the injury site, but did not prevent proliferation of GDAsBMP or inhibit their effects in reducing the spinal cord lesion cavity.
• 2
  GDAsBMP prevented cavity formation in the early stages of spinal cord injury. The size of the cavity was notably smaller at every time point from 3 days after surgery, compared with the model group.
• 3
  Combined administration of olomoucine and GDAsBMP had a significantly greater effect on the restoration of motor function than either treatment alone.