Temporospatial Expression and Cellular Localization of Oligodendrocyte Myelin Glycoprotein (OMgp) after Traumatic Spinal Cord Injury in Adult Rats

Following spinal cord injury (SCI), the adult mammalian central nervous system (CNS) has limited ability to regenerate axons, resulting in permanent neurological deficits. One of the reasons is thought to be the presence of myelin-associated inhibitors, such as oligodendrocyte myelin glycoprotein (OMgp). This study created a specific OMgp polyclonal antibody to investigate OMgp expression after SCI. The study found increased OMgp mRNA and protein levels after SCI. OMgp was found localized in neurons and oligodendrocytes. The research suggests that OMgp may play a role in inhibiting axonal regeneration after spinal cord injury. By understanding OMgp's role, future treatments might target this molecule to promote nerve repair.

• 1
  OMgp was almost exclusively expressed in the CNS, with slight expression in cardiac muscle and liver. It was not found in lung, kidney, or skeletal muscle.
• 2
  Following SCI, both OMgp mRNA and protein levels were elevated, peaking at 28 days post-SCI compared to sham-operated controls.
• 3
  OMgp was exclusively localized in neurons and oligodendrocytes in normal and sham-operated controls, with increased expression in these cells following SCI.