The Effectiveness of Intravesical Oxybutynin, Propantheline, and Capsaicin in the Management of Neuropathic Bladder following Spinal Cord Injury
TheScientificWorldJOURNAL, 2007 · DOI: 10.1100/tsw.2007.271 · Published: October 22, 2007
Simple Explanation
Neuropathic bladder after spinal cord injury can lead to urinary incontinence and kidney problems. This study explores using medications directly in the bladder to manage this issue. The study compares oxybutynin, propantheline, and capsaicin, delivered directly into the bladder, to see which is most effective in reducing bladder overactivity. The goal is to find a treatment that reduces the systemic side effects often caused by oral medications, while still improving bladder control.
Key Findings
- 1Intravesical capsaicin significantly improved reflex volume, cystometric capacity, leak volume, and leak frequency in treating neurogenic detrusor overactivity.
- 2Propantheline showed more improvement than oxybutynin for reflex volume, detrusor leak point pressure, clean intermittent catheterization volume, and leak volume.
- 3Significant differences were found in the therapeutic response between oxybutynin, propantheline, and capsaicin for leak volume and leak frequency at 2 weeks.
Research Summary
Practical Implications
Alternative Treatment Option
Intravesical agents can serve as effective adjuvants in managing incontinence due to overactive neuropathic bladders following SCI, offering an alternative to systemic medications.
Personalized Treatment
The varying responses to oxybutynin, propantheline, and capsaicin suggest the need for personalized treatment approaches based on individual patient profiles.
Further Research
Further research is warranted to optimize the dosage and administration protocols for intravesical capsaicin to maximize its therapeutic benefits.
Study Limitations
- 1Small sample size
- 2Lack of blinding for capsaicin instillation
- 3Short follow-up period