The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

Mediators of Inflammation, 2023 · DOI: https://doi.org/10.1155/2023/5127157 · Published: February 8, 2023

Mental Health Neurology Gastroenterology

Simple Explanation

The study reviews the link between gut microbiota and neurological/psychiatric disorders. It explores how different types of gut bacteria are related to conditions like Alzheimer's, ADHD, and depression. Researchers looked at existing systematic reviews and meta-analyses, assessing their quality using a tool called AMSTAR-2. They mapped out which bacteria are associated with which diseases. The findings show varied levels of evidence for these links. Some bacteria increase disease risk, while others may be helpful, suggesting potential new treatment targets.

Study Duration

Not specified

Participants

42 studies

Evidence Level

Evidence Mapping of Systematic Reviews and Meta-Analyses

Key Findings

1
Many studies have investigated the link between gut microbiome alpha diversity and disease, with the Shannon and Simpson indices being the most studied.
2
Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia are the most researched phyla.
3
Some diseases exhibit specific flora changes, while others share common intestinal microbiological changes.

Research Summary

This evidence mapping summarizes associations of gut microbiota with neurological or psychiatric disorders, identifying common or differential gut microbiota present in different disorders, which may afford opportunities for understanding aetiology and making targeted treatment strategies. The study found that research is limited regarding gut microbiomes among individuals with SCI, stroke, and AD, even though gastrointestinal symptoms are often comorbid with these conditions. The researchers observed that certain diseases, such as ADHD, AN, and BD, as well as AD, ADHD, ALS, GAD, and MDD, overlapped in categories of abundance changes, suggesting that these overlaps may be related to transdiagnostic pathophysiology.

Practical Implications

Targeted Therapies

Identifying specific gut bacteria linked to diseases allows for targeted therapies like probiotics, dietary changes, or fecal transplants.

Transdiagnostic Understanding

Overlapping microbial changes in different neurological/psychiatric conditions suggest shared underlying mechanisms.

Personalized Medicine

Understanding individual microbiota compositions can lead to personalized treatment strategies for neurological and psychiatric disorders.

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

Simple Explanation

Key Findings

Research Summary

Practical Implications

Targeted Therapies

Transdiagnostic Understanding

Personalized Medicine

Study Limitations

Your Feedback

Was this summary helpful?

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

Simple Explanation

Key Findings

Research Summary

Practical Implications

Targeted Therapies

Transdiagnostic Understanding

Personalized Medicine

Study Limitations

Your Feedback

Was this summary helpful?