Journal of Biomedical Optics, 2024 · DOI: 10.1117/1.JBO.29.S1.S11526 · Published: March 19, 2024
This paper introduces a new method called photoacoustic differential attenuation spectrum (PA-DAS) to study cancellous bone, which is important for diagnosing osteoporosis. The method separates how sound travels through the bone from the original sound source, allowing for a more detailed analysis of bone structure and its changes due to osteoporosis. The study combines theoretical calculations with experiments on rabbits to show that PA-DAS can effectively distinguish between healthy and osteoporotic bone.
PA-DAS facilitates quantitative assessment of bone mineral density, leading to earlier and more accurate osteoporosis diagnosis.
The method has potential utility for comprehensive bone quality assessment by decoupling the PA signals.
Lays a foundation for further photoacoustic imaging (PAI) study of bone marrow distribution in cancellous bone.