Transcriptomic responses to wounding: meta-analysis of gene expression microarray data

This study analyzes gene expression changes after injury in different tissues and organisms. The meta-analysis compares gene expression profiles in response to wounding in tissues like heart, liver, skin, bones, and spinal cord, and species like rat, mouse and human. The study identifies genes with significant expression changes after wounding and compares them across different wound healing stages.

• 1
  Transcriptomic responses in early wound healing phases showed little consistency between tissues.
• 2
  Later phases of wound repair and remodelling showed similar transcriptional responses across tissues.
• 3
  Inflammatory genes were induced not only initially but also during repair and remodelling.