Transplantation of the LRP1high subpopulation of human umbilical cord‑derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Stem Cell Research & Therapy, 2024 · DOI: https://doi.org/10.1186/s13287-024-03660-0 · Published: February 7, 2024

Women's Health Regenerative Medicine & Stem Cells

Simple Explanation

Premature ovarian failure (POF) significantly impacts female reproductive and psychological well-being. Transplanting umbilical cord-derived mesenchymal stem cells (UC-MSCs) shows promise for treating POF. Identifying specific UC-MSC subpopulations with the ability to improve ovarian function is vital for effective POF treatment.

Study Duration

Not specified

Participants

Female and male ICR mice; human UC-MSCs

Evidence Level

Not specified

Key Findings

1
Human UC-MSCs can be divided into three subtypes: mesenchymal stem cells, multilymphoid progenitor cells, and trophoblasts.
2
The LRP1high subpopulation of UC-MSCs improved ovarian function in aged and POF mice.
3
The LRP1high subpopulation improves ovarian function by modulating the extracellular matrix of oocytes, NAD metabolism, and mitochondrial function in granulosa cells.

Research Summary

This study explored the heterogeneity of human UC-MSCs and identified the LRP1high subpopulation as capable of improving ovarian function in aged and POF mice. The LRP1high subpopulation improves ovarian function by secreting various factors and remodeling the extracellular matrix. This research provides insights for targeted exploration of human UC-MSCs in precise POF treatment.

Practical Implications

Targeted POF Treatment

The identification of the LRP1high subpopulation allows for a more targeted and precise approach to stem cell therapy for POF.

Improved Ovarian Function

Transplantation of the LRP1high subpopulation can effectively restore abnormal hormone levels, shorten estrous cycles, and increase the number of follicles in POF mice.

Enhanced Oocyte Quality

The LRP1high subpopulation improves oocyte quality by regulating pathways related to ECM, DNA damage, and NAM metabolism.

Study Limitations

1
Heterogeneity among stem cells from different tissues affects the reproducibility of stem cell therapies.
2
Variability across different generations and samples also significantly affects the reproducibility of stem cell therapies
3
Further research is needed to delineate and screen for the primary secretion factors of LRP1high subpopulation.

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Transplantation of the ­LRP1high subpopulation of human umbilical cord‑derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Simple Explanation

Key Findings

Research Summary

Practical Implications

Targeted POF Treatment

Improved Ovarian Function

Enhanced Oocyte Quality

Study Limitations

Your Feedback

Was this summary helpful?

Transplantation of the ­LRP1high subpopulation of human umbilical cord‑derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Simple Explanation

Key Findings

Research Summary

Practical Implications

Targeted POF Treatment

Improved Ovarian Function

Enhanced Oocyte Quality

Study Limitations

Your Feedback

Was this summary helpful?

Transplantation of the LRP1high subpopulation of human umbilical cord‑derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Transplantation of the LRP1high subpopulation of human umbilical cord‑derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice