Utilizing a low-carbohydrate/high-protein diet to improve metabolic health in individuals with spinal cord injury (DISH): study protocol for a randomized controlled trial

Trials, 2019 · DOI: https://doi.org/10.1186/s13063-019-3520-3 · Published: September 5, 2019

Simple Explanation

This study explores how a low-carbohydrate, high-protein diet might improve metabolic health in people with spinal cord injuries. Metabolic disorders are more common in this population. The study will involve 100 participants with SCI who will be randomly assigned to either follow an 8-week low-carbohydrate, high-protein diet or continue with their regular diet. The researchers will then examine the effects on glucose control, body composition, gut bacteria, and quality of life. The goal is to find a cost-effective dietary intervention that can improve metabolic function and overall health in individuals with chronic SCI.

Study Duration
8 weeks
Participants
100 participants with chronic traumatic SCI
Evidence Level
Level 1: Randomized controlled trial

Key Findings

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    The study aims to determine if a low-carbohydrate/high-protein diet improves glucose tolerance, insulin sensitivity, and β-cell function in individuals with SCI.
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    Researchers will assess changes in body composition, specifically increases in lean mass and decreases in total and visceral fat mass.
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    The study will also examine how the dietary intervention affects the composition of gut bacteria and the overall quality of life for participants.

Research Summary

This study investigates the effects of an 8-week low-carbohydrate/high-protein (LC/HP) dietary intervention on metabolic health, body composition, gut bacteria composition, and quality of life in individuals with spinal cord injury (SCI). One hundred participants with chronic traumatic SCI and insulin resistance, impaired glucose tolerance, or untreated type 2 diabetes will be randomly assigned to either an LC/HP dietary intervention group or a control group. The study aims to provide new information for developing a cost-effective dietary intervention to improve metabolic function in individuals with chronic SCI and to understand the relationship between metabolic function and quality of life in this population.

Practical Implications

Development of Dietary Intervention

The project aims to develop a low-cost, simple, self-administered LC/HP dietary intervention for improving metabolic function in individuals with chronic SCI.

Improved Understanding of Gut Bacteria

The study seeks to improve understanding of the composition of gut bacteria in SCI and how a LC/HP dietary intervention alters gut bacteria composition.

Enhanced Quality of Life

The project will improve understanding of the relationship between metabolic function and quality of life in individuals with long-standing SCI.

Study Limitations

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