Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy

Nature Communications, 2024 · DOI: 10.1038/s41467-024-55152-7 · Published: December 10, 2024

Simple Explanation

The study introduces NeuroStep, a wearable device designed to restore lost sensation in individuals with peripheral neuropathy (PN) by stimulating nerves at the ankle level. The device was tested on 14 participants with PN, and results showed a partial restoration of lost sensations, improved gait, and reduced neuropathic pain after just one day of use. Brain imaging revealed that the sensations restored by NeuroStep activated brain areas similar to those activated by natural foot sensations, suggesting an intuitive integration of the artificial feedback.

Study Duration

One day study

Participants

14 PN participants, 22 healthy controls, 5 PN participants and 12 healthy controls for fMRI

Evidence Level

Not specified

Key Findings

1
NeuroStep partially restored lost sensations in all 14 PN participants through targeted neurostimulation at the ankle level.
2
Participants experienced improvements in cadence and functional gait, along with a decrease in neuropathic pain, after one day of using the NeuroStep system.
3
fMRI results indicated that restored sensations activated cortical patterns resembling naturally located foot sensations, suggesting intuitive sensory integration.

Research Summary

This study introduces and validates NeuroStep, a wearable neuroprosthesis designed to restore lost foot sensations in individuals with peripheral neuropathy (PN) through targeted neurostimulation at the ankle level. The device's functionality was assessed in 14 PN participants, demonstrating partial restoration of lost sensations, improvements in gait and balance, and reduction in neuropathic pain after a single day of use. Brain imaging (fMRI) revealed that the artificially restored sensations activated similar cortical areas as natural foot sensations, supporting the potential for intuitive integration of the neuroprosthesis.

Practical Implications

Improved Mobility

The neuroprosthesis can enhance mobility and reduce fall risk in PN patients.

Pain Management

Targeted neurostimulation can provide relief from neuropathic pain.

Enhanced Sensory Feedback

Restoring sensory feedback can improve the quality of life for individuals with sensory loss.