A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection

This study introduces a novel nanoparticle, PMC NPs, designed to combat oxidative stress and inflammation in neural diseases. It combines the ROS scavenging ability of a nanozyme with the anti-inflammatory properties of curcumin. The PMC NPs exhibit excellent dispersibility, cytocompatibility, and enzyme-mimetic activities, specifically SOD-like and CAT-like activities, which are crucial for neutralizing harmful reactive oxygen species (ROS). The curcumin component further enhances the anti-inflammatory effect by suppressing the expression of inflammatory cytokines. In vitro experiments demonstrated that PMC NPs effectively scavenged ROS in microglia and neuronal cells, mitigated DNA and lipid oxidation, and increased cell viability under oxidative stress, suggesting their potential as therapeutic agents for neural diseases.

• 1
  PMC NPs exhibit specific SOD-like and CAT-like activities, enabling them to effectively scavenge ROS in physiological conditions.
• 2
  The incorporation of curcumin into PMC NPs enhances their anti-inflammatory capabilities, suppressing the expression of inflammatory cytokines in microglia induced by LPS.
• 3
  PMC NPs effectively mitigate DNA and lipid oxidation in neuronal cells and increase cell viability under H2O2-induced oxidative stress, demonstrating their neuroprotective potential.