Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 1-10 of 525 results
Regenerative Therapy, 2024 • September 23, 2024
This study investigates a novel approach to spinal cord injury treatment by combining the anti-inflammatory properties of Laurus nobilis extract (LNE) with the regenerative capabilities of adipose-der...
KEY FINDING: Laurus nobilis extract-loaded scaffolds reduced tissue expression levels of pro-inflammatory cytokines like TNF-a, IL-1b, and IL-6.
International Journal of Spine Surgery, 2022 • November 21, 2022
This study examined the effect of smoking on motor recovery in patients with American Spinal Injury Association (ASIA) grade D cervical traumatic spinal cord injury (TSCI). The research found that pat...
KEY FINDING: Smokers had worse improvement in motor score at 1 year compared to nonsmokers (4.61 vs 7.99, P = 0.019).
Journal of Cachexia, Sarcopenia and Muscle, 2023 • February 13, 2023
This systematic review and meta-analysis investigated the association between sarcopenia and polypharmacy/number of medications in older adults. The analysis of 29 studies revealed a significantly inc...
KEY FINDING: Sarcopenia was associated with a higher prevalence of polypharmacy (OR: 1.65, 95% CI [1.23, 2.20], I2 = 84%, P < 0.01).
Global Spine Journal, 2024 • July 1, 2024
This study aimed to compare the efficacy of riluzole, methylprednisolone (MPS), and their combination in treating acute spinal trauma in a rat model, using electrophysiological and histopathological a...
KEY FINDING: Electrophysiologically, no treatment provided significant improvement compared to the control group in terms of latency and amplitude.
Cureus, 2023 • April 14, 2023
This study focused on developing and validating the Upper Extremity Functional Skill Measure (UEFSM), a 10-item tool designed to assess hand function in individuals with C5-C7 spinal cord injury (SCI)...
KEY FINDING: The developed UEFSM is a 10-item tool that assesses hand function across four subscales: grasp, grip, pinch, and gross movement.
CNS Neurosci Ther, 2023 • January 1, 2023
This study investigates the role of bile acids and their receptors, TGR5 and FXR, in alleviating neuropathic pain induced by spared nerve injury (SNI) in mice. The results demonstrate that SNI leads t...
KEY FINDING: Bile acid levels are decreased in the spinal dorsal horn after spared nerve injury (SNI), while CYP7A1 expression is upregulated in microglia.
The Journal of Spinal Cord Medicine, 2024 • March 8, 2023
This study aimed to identify common, potentially harmful drug interactions in individuals with spinal cord injury (SCI) and associated risk factors. The study found that almost three out of ten indivi...
KEY FINDING: Almost three out of ten individuals with spinal cord injury were at risk of having a potentially harmful drug interaction.
PLOS ONE, 2023 • April 20, 2023
This scoping review aimed to identify and summarize existing literature on medication self-management interventions for adults with traumatic SCI. The review identified only three relevant studies, hi...
KEY FINDING: There is a lack of literature on medication self-management interventions specifically designed for adults with traumatic SCI.
Pain Ther, 2023 • April 28, 2023
This multinational, open-label study assessed the long-term safety and efficacy of mirogabalin for central neuropathic pain (CNeP) in Asian patients with spinal cord injury (CNePSCI), Parkinson's dise...
KEY FINDING: Mirogabalin was generally safe and well-tolerated, with common side effects including somnolence, peripheral edema, edema, and dizziness, most of which were mild.
Cells, 2023 • May 6, 2023
This study investigates a multi-faceted therapeutic approach for spinal cord injury (SCI), combining nanomedicines (NMeds) loaded with triiodothyronine (T3), systemic ibuprofen, and mouse nerve growth...
KEY FINDING: The "combo" therapy reduced M1 microglia activation and glutamate levels in the short term, indicating a strong anti-inflammatory effect.