A single-blind randomized control trial of trigonal versus nontrigonal Botulinum toxin-A injections for patients with urinary incontinence and poor bladder compliance secondary to spinal cord injury

This study investigates whether injecting Botulinum toxin-A (BTX-A) into the trigone area of the bladder, in addition to the detrusor muscle, is more effective for patients with urinary incontinence and poor bladder compliance due to spinal cord injury. Patients were divided into two groups: one receiving BTX-A in both the detrusor and trigone, and the other receiving BTX-A only in the detrusor. The study measured urodynamic outcomes, UI episodes, voiding volume and quality of life to determine which injection method was more effective and safe.

• 1
  Trigonal BTX-A injection is more effective and safer than nontrigonal BTX-A injection for SCI patients with UI secondary to neurogenic-poor BC and does not result in VUR.
• 2
  Patients in the experimental group showed greater improvement in detrusor leak point volume (DLPV) than that in the control group.
• 3
  The experimental group showed greater increase in bladder voiding volume than those in the control group.