An Engineered Bionic Nanoparticle Sponge as a Cytokine Trap and Reactive Oxygen Species Scavenger to Relieve Disc Degeneration and Discogenic Pain

This study addresses the challenges of disc degeneration and discogenic pain by introducing a novel nanomaterial, MnO2@TMNP. This material is designed to target inflammation and promote tissue regeneration within the intervertebral discs. The engineered nanoparticle works by neutralizing inflammatory factors and reactive oxygen species (ROS) in the disc microenvironment. This action helps to reduce cell death, promote matrix regeneration, and alleviate pain. Animal model results showed that the nanomaterial effectively reduced disc degeneration and relieved pain-related behaviors. The improved outcomes are attributed to reduced inflammation and nerve sensitization in the spinal cord and dorsal root ganglion.

• 1
  MnO2@TMNP effectively binds inflammatory factors and nerve growth factors, inhibiting inflammation-induced apoptosis and nerve ingrowth.
• 2
  The macrophage cell membrane of MnO2@TMNP facilitates targeted delivery of MnO2 nanoparticles to macrophages, scavenging intracellular ROS and preventing M1 polarization.
• 3
  In a rat injured disc model, MnO2@TMNP prevented disc inflammation, promoted matrix regeneration, and alleviated mechanical and thermal hyperalgesia.