Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1-10 of 220 results
BMC Pulmonary Medicine, 2024 • October 7, 2024
This study investigated the relationship between plasma fibrinogen levels and the incidence of pulmonary infection (PI) in patients with spinal cord injury (SCI). The study found that elevated plasma ...
KEY FINDING: For every 1 g/L increase in fibrinogen level, the risk of developing PI increased by 18% (HR = 1.18, P = 0.011), and indicating a positive linear relationship between fibrinogen level and PI incidence.
Neural Regeneration Research, 2023 • April 1, 2023
This review summarizes the progress in reprogramming astrocytes into neurons in vivo in animal models of various CNS conditions. The focus is on spinal cord injury, brain injury, Huntington’s disease,...
KEY FINDING: Astrocytes in the mature CNS can be reprogrammed into functional neurons in vivo, offering a potential avenue for nerve regeneration.
Neural Regeneration Research, 2023 • October 11, 2022
This study investigates the role of thrombin in regulating cholesterol metabolism in astrocytes following spinal cord injury (SCI) in rats. The results demonstrate that SCI-induced thrombin activation...
KEY FINDING: Spinal cord injury increases thrombin and CH25H expression in rat astrocytes.
Neural Regeneration Research, 2023 • December 21, 2022
This article reviews research on the mechanistic roles of purinergic receptors in spinal cord injury, highlighting the potential role of purinergic receptors as interventional targets for neural repai...
KEY FINDING: Activation of adenosine A1 and A3 receptors can exert neuroprotective effects after CNS injury by inhibiting glutamate release and reducing Ca2+ accumulation.
Neural Regeneration Research, 2023 • December 21, 2022
This study investigates the role of macrophage migration inhibitory factor (MIF) in the production of the chemokine CCL2 by astrocytes following spinal cord injury (SCI). The findings demonstrate that...
KEY FINDING: MIF levels significantly increase at the lesion site after SCI, coinciding with elevated CCL2 production.
Neural Regeneration Research, 2023 • October 11, 2022
This study explored the protective role of PARP14 in SCI, finding that PARP14 expression increases at the injury site in a mouse model of SCI, and its knockdown worsens SCI. Both in vivo and in vitro ...
KEY FINDING: PARP14 expression is upregulated in spinal cord tissues after SCI, suggesting a compensatory mechanism.
Neural Regen Res, 2023 • January 30, 2023
Spinal cord injury leads to neuronal death, with ferroptosis being a key contributor to dysfunction. Emerging treatments like MSC, EV, and TMS therapy offer hope by potentially inhibiting neuronal dea...
KEY FINDING: Ferroptosis, a form of cell death, significantly contributes to neurological dysfunction following spinal cord injury.
Redox Biology, 2023 • March 20, 2023
This study elucidates the protective role of Git1 in spinal cord ischemia-reperfusion injury (SCIRI), demonstrating that Git1 deletion impairs functional recovery in mice. The research uncovers a nove...
KEY FINDING: Deletion of Git1 in mice resulted in poorer recovery of spinal cord motor function after SCIRI, indicating Git1's protective role.
Neural Regen Res, 2023 • March 3, 2023
Spinal cord injury (SCI) results in the interruption of axonal connections, leading to motor, sensory, and autonomic dysfunction. Mitochondrial dysfunction during the secondary stage of SCI exacerbate...
KEY FINDING: Mitochondrial dysfunction is intimately linked with axonal regeneration failure in the context of spinal cord injury.
Mediators of Inflammation, 2023 • April 10, 2023
This study investigated the effects of AdipoRon on neuropathic pain (NeuP) in mice, focusing on its impact on microglia and the AdipoR1/AMPK pathway. The results showed that AdipoRon alleviated mechan...
KEY FINDING: AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.