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Antifungal efficacy of natamycin in experimental keratitis

International Journal of Ophthalmology, 2012 · DOI: 10.3980/j.issn.2222-3959.2012.02.05 · Published: April 18, 2012

PharmacologyImmunology

Simple Explanation

This study evaluates the effectiveness of Natamycin, a drug produced in China, for treating fungal keratitis (a fungal infection of the cornea) in rabbits. The researchers compared Natamycin to Natacyn (a standard treatment) and a saline control group, observing the healing process and any complications. The results showed that Natamycin was as effective as Natacyn in treating fungal keratitis in rabbits, suggesting it could be a safe and accessible alternative.

Study Duration
21 days
Participants
30 New Zealand rabbits
Evidence Level
Not specified

Key Findings

  • 1
    Natamycin and Natacyn groups showed significantly better ulcer scores compared to the control group on days 10, 15, and 21.
  • 2
    The cure rates for both Natamycin and Natacyn groups were 90% and 80% respectively on day 10, reaching 100% by day 21.
  • 3
    Both Natamycin and Natacyn significantly reduced corneal vascularization, iritis, hypopyon, and macular nebula compared to the control group.

Research Summary

The study aimed to evaluate the efficacy of topical Natamycin, produced in China, in treating fungal keratitis using a rabbit model. Rabbits with induced keratitis were treated with Natamycin, Natacyn, or saline solution, and their eyes were examined for healing status and complications. The results indicated that Natamycin is as effective as Natacyn in treating fungal keratitis and preventing complications, suggesting it is a viable treatment option.

Practical Implications

Clinical Application

Natamycin manufactured in China can be used as an effective alternative to Natacyn for treating fungal keratitis, especially where Natacyn is not readily available or is too expensive.

Economic Impact

The availability of a domestically produced Natamycin can reduce the cost of treating fungal keratitis, particularly in developing countries.

Further Research

Further clinical trials on humans are warranted to confirm the efficacy and safety of Chinese-produced Natamycin for treating fungal keratitis.

Study Limitations

  • 1
    The study was conducted on rabbits, and the results may not be directly applicable to humans.
  • 2
    The study only evaluated one specific brand of Chinese-produced Natamycin.
  • 3
    The long-term effects of Natamycin treatment were not assessed.

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