Association of Inflammation, Ectopic Bone Formation, and Sacroiliac Joint Variation in Ossification of the Posterior Longitudinal Ligament

This study investigates the relationship between inflammation, spinal ligament ossification (OPLL), and changes in the sacroiliac (SI) joint. The research categorizes ossification lesions into plateau and hill shapes and examines their connection to hs-CRP levels and SI joint changes. The study suggests a possible inflammation mechanism that contributes to new bone formation in OPLL, particularly in the plateau shape.

• 1
  The plateau shape of OPLL was more common in vertebral segments, while the hill shape was predominant in intervertebral regions.
• 2
  Serum hs-CRP levels were significantly higher in the plateau-shaped group compared to the hill-shaped group.
• 3
  SI joint intra-articular fusion was the main finding in the plateau-shaped group and showed significantly higher hs-CRP levels compared to anterior para-articular bridging.