Attenuation of TRPV1 by AMG-517 after nerve injury promotes peripheral axonal regeneration in rats

Peripheral nerves can regenerate after injury, but this process is often slow and incomplete. This study explores whether blocking a specific protein, TRPV1, after a nerve injury can help. The researchers used a drug called AMG-517 to block TRPV1 in rats with sciatic nerve injuries. They then looked at nerve regeneration and the expression of certain proteins. The results showed that blocking TRPV1 with AMG-517 promoted nerve regeneration. This suggests that TRPV1 could be a potential target for therapies to improve nerve repair after injury.

• 1
  Blockage of TRPV1 with AMG-517 markedly promoted axonal regeneration, especially at two weeks after sciatic injury.
• 2
  Expression of glial fibrillary acidic protein was decreased and GAP-43 was increased at the proximal stump after sciatic nerve transection with AMG-517 treatment.
• 3
  AMG-517 treatment increased the elimination of degraded debris by infiltration of macrophages and pinocytosis, providing a good environment for nerve branching and Schwann cell proliferation.