Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 1-10 of 248 results
Journal of Molecular Neuroscience, 2024 • October 17, 2024
This study examined the effects of different electroacupuncture (EA) frequencies (2 Hz, 100 Hz, and 18 kHz) on neuropathic pain in mice with sciatic nerve damage. Analgesic effects were evaluated by m...
KEY FINDING: The analgesic effect of EA on neuropathic pain in mice was frequency-dependent.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study investigated the prevalence and predictors of publicly funded prescription opioid use among individuals with traumatic spinal cord injury (TSCI) in Ontario, Canada. The study found that ove...
KEY FINDING: Over half (55%) of individuals with TSCI who are eligible for Ontario's public drug program used opioids in the year following their injury.
Cureus, 2024 • February 1, 2024
This case report highlights a rare instance of position-dependent intrathecal baclofen catheter failure, leading to debilitating spasticity and withdrawal symptoms in a young quadriplegic male. The st...
KEY FINDING: The initial catheter anchoring occurred directly adjacent to the vertebrae, leading to a position-dependent catheter occlusion.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
This study investigated the misuse of gabapentinoids in patients with neuropathic pain related to spinal cord injury, finding a high prevalence of misuse, particularly with pregabalin. The study ident...
KEY FINDING: The misuse rate was 81.9% in patients using pregabalin and 69.69% in patients using gabapentin.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study evaluated the perceived helpfulness of various treatments for neuropathic pain (NeuP) following spinal cord injury (SCI). The research involved a multicenter cross-sectional survey of 391 i...
KEY FINDING: Non-tramadol opioids, cannabinoids, and anti-epileptics were the pharmacological treatments most often rated as helpful for neuropathic pain.
The Journal of Spinal Cord Medicine, 2024 • September 8, 2022
The mechanisms of the predictive effects of pain severity on school/work functioning in youth with SCI are explained in part by the serial multiple mediator effects of pain interference and social fun...
KEY FINDING: Pain predictive effects on school/work functioning were serially mediated by pain interference and social functioning.
Neural Regeneration Research, 2023 • November 25, 2022
The study investigated the effects of exercise combined with adipose-derived stem cells (ADSCs) on neuropathic pain after spinal cord injury (SCI) in a mouse model. The results demonstrated that the c...
KEY FINDING: Exercise combined with ADSC administration partially improved early motor function recovery after SCI.
CNS Neurosci Ther, 2023 • January 1, 2023
This study investigates the role of bile acids and their receptors, TGR5 and FXR, in alleviating neuropathic pain induced by spared nerve injury (SNI) in mice. The results demonstrate that SNI leads t...
KEY FINDING: Bile acid levels are decreased in the spinal dorsal horn after spared nerve injury (SNI), while CYP7A1 expression is upregulated in microglia.
Mediators of Inflammation, 2023 • April 10, 2023
This study investigated the effects of AdipoRon on neuropathic pain (NeuP) in mice, focusing on its impact on microglia and the AdipoR1/AMPK pathway. The results showed that AdipoRon alleviated mechan...
KEY FINDING: AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.
Frontiers in Behavioral Neuroscience, 2023 • April 4, 2023
This study aimed to explore the effect of tDCS on neuropathic pain induced by SCI and its underlying mechanism, focusing on the role of microglia and cytokines. The results indicate that tDCS can effe...
KEY FINDING: tDCS treatment improved thermal withdrawal threshold and motor function in SCI rats compared to the vehicle group.