Autologous Platelet-Rich Plasma Administration on the Intervertebral Disc in Low Back Pain Patients with Modic Type 1 Change: Report of Two Cases

This study investigates the use of platelet-rich plasma (PRP) injections in the intervertebral discs of patients with low back pain (LBP) and Modic type 1 changes, which are signs of inflammation in the spine. PRP is derived from the patient's own blood and contains growth factors that may help with tissue repair and reduce inflammation. The study followed two patients who received PRP injections to evaluate the safety and effectiveness of this treatment. The findings suggest that PRP injections might be a safe and potentially effective treatment for LBP associated with Modic type 1 changes, as both patients showed some improvement in pain scores and MRI scans indicated reduced inflammation.

• 1
  There were no adverse events in physical condition, laboratory data, or lumbar X-rays after injection, suggesting that PRP intradiscal injection is safe.
• 2
  Follow-up MRI showed a decrease of high signal intensity on T2WI compared to before PRP administration, indicating reduced inflammation.
• 3
  The pain scores tended to improve after the injection, as measured by VAS, ODI, and RDQ.