Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury

Spinal cord injury (SCI) stimulates activation of astrocytes and infiltration of immune cells at the lesion site. The study explores the neuroregenerative properties of co-ultraPEALut in a murine model of SCI. Mice were treated with co-ultraPEALut (1 mg/kg, intraperitoneally) daily for 72 h after SCI. The treatment increased the numbers of bromodeoxyuridine-positive nuclei and doublecortin-immunoreactive cells. Co-ultraPEALut administration stimulated expression of the neurotrophic factors brain-derived neurotrophic factor, glial cell-derived neurotrophic factor, nerve growth factor, and neurotrophin-3. These findings show a prominent effect of co-ultraPEALut administration in the management of survival and differentiation of new neurons and spine maturation.

• 1
  Co-ultraPEALut increased the numbers of both bromodeoxyuridine-positive nuclei and doublecortin-immunoreactive cells in the spinal cord of injured mice, indicating increased cell proliferation and neurogenesis.
• 2
  Co-ultraPEALut administration stimulated expression of the neurotrophic factors brain-derived neurotrophic factor, glial cell-derived neurotrophic factor, nerve growth factor, and neurotrophin-3, suggesting a mechanism for promoting neuronal survival and differentiation.
• 3
  Co-ultraPEALut administration stimulated the remodeling of dendritic arbors in the injured area, indicating an effect on synaptic plasticity and neuronal circuit reorganization.