Correction to: Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

Military Med Res, 2021 · DOI: 10.1186/s40779-021-00312-9 · Published: May 12, 2021

Neurology Genetics Regenerative Medicine & Stem Cells

Simple Explanation

This article is a correction to a previously published paper regarding the conversion of astrocytes into motor neuron-like cells using small molecules. The correction involves replacing incorrect figures in the original publication with the correct ones. Supplementary information details morphological changes in astrocytes after treatment with various small molecules and combinations thereof.

Study Duration

5 days induction for morphological changes

Participants

Human astrocytes (HA1800)

Evidence Level

Not specified

Key Findings

1
Small molecules can induce morphological changes in human astrocytes, converting them into neuron-like cells.
2
Different combinations of small molecules (KFYPR, CFYPR, FYPR) induce varying morphological changes and neurite lengths in treated astrocytes.
3
Induced cells express neuronal markers like TUJ1, HB9 and ISL1 and exhibit electrophysiological properties of motor neurons.

Research Summary

This is a correction article addressing errors in figures in a previous publication regarding the conversion of astrocytes to motor neuron-like cells using small molecules. The corrected figures and supplementary information provide details on the morphological changes induced by different small molecule treatments on human astrocytes. The study demonstrates the rapid conversion of astrocytes into neuron-like cells with specific neuronal markers and electrophysiological properties.

Practical Implications

Improved Data Accuracy

Ensures the accuracy and reliability of published scientific findings by correcting errors in figures.

Advancement of Cell Conversion Techniques

Provides further insight into the use of small molecules for converting astrocytes into motor neuron-like cells, which may have applications in regenerative medicine.

Potential Therapeutic Applications

Understanding the mechanisms of astrocyte conversion could lead to new therapeutic strategies for neurodegenerative diseases.

Study Limitations

1
The article is a correction and does not present new experimental data.
2
The study focuses on in vitro conversion of astrocytes; in vivo applications require further investigation.
3
The long-term effects and stability of the converted motor neuron-like cells are not addressed.

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