Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn

Spinal cord injury (SCI) is a serious condition with limited effective treatments. It often leads to inflammation and activation of specific pathways in the spinal cord, contributing to further damage. Daphnoretin, a natural compound, has shown promise in reducing inflammation in other diseases. This study investigates whether Daphnoretin can reduce inflammation and improve motor function after SCI by targeting the NF-κB pathway. The study found that Daphnoretin can inhibit the activation of the NF-κB pathway and the inflammatory response induced by SCI. This suggests it could be a potential treatment for SCI.

• 1
  Daphnoretin attenuated the loss of movement ability in mice after SCI, suggesting it has a protective effect on motor function.
• 2
  Daphnoretin inhibited the activation of glial cells (microglia and astrocytes) in the spinal dorsal horn of mice after SCI, indicating a reduction in neuroinflammation.
• 3
  Daphnoretin inhibited the activation of the NF-κB pathway and the expression of inflammatory factors TNF-α and IL-1β both in vivo (in mice) and in vitro (in cell cultures).