Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain

Molecular Pain, 2022 · DOI: 10.1177/17448069211060181 · Published: January 1, 2022

Simple Explanation

This study investigates how different types of spinal cord stimulation (SCS) affect the levels of proteins involved in controlling the movement of ions in the spinal cord of rats with nerve pain. The researchers compared a newer SCS method called differential target multiplexed programming (DTMP) to a more traditional low-rate (LR) SCS. They found that DTMP SCS affected a larger number of proteins related to ion transport than LR SCS, suggesting it may be more effective at restoring normal nerve function and reducing pain.

Study Duration

48 h

Participants

Male Sprague-Dawley rats (n = 10 per group)

Evidence Level

Not specified

Key Findings

1
DTMP modulated a larger number of proteins involved in ion transport regulation compared to LR SCS.
2
DTMP modulated proteins involved in glial response to neural injury, affecting calcium signaling.
3
DTMP upregulated presynaptic proteins involved in GABA vesicle formation and release, and modulated proteins that regulate postsynaptic chloride inhibition.

Research Summary

The study evaluated the effect of differential target multiplexed programming (DTMP) spinal cord stimulation (SCS) on proteins involved in ion transport regulation in the spinal cord of rats with neuropathic pain, compared to low rate (LR) SCS. DTMP modulated a larger number of proteins than LR, particularly those involved in the regulation of chloride, potassium, sodium, and calcium ions. DTMP treatment modulated the expression of proteins with the potential to facilitate a reversal of dysregulation of ion transport and signaling associated with a model of neuropathic pain.

Practical Implications

Improved SCS Programming

DTMP may offer a more effective approach to SCS programming for neuropathic pain by targeting a broader range of ion transport-related proteins.

GABA Enhancement

The upregulation of GABA-related proteins suggests DTMP could enhance inhibitory signaling in the spinal cord, reducing pain.

Glial Cell Modulation

Modulating glial cell activity, particularly calcium signaling, may be a key mechanism by which DTMP achieves pain relief.

Study Limitations

1
Inclusion of only male subjects may limit the generalizability of the findings.
2
The study represents an early snapshot in the evolution of chronic neuropathic pain.
3
The analysis was limited to the dorsal ipsilateral quadrant of the stimulated cord.

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