DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

Ossification of the posterior longitudinal ligament (OPLL) is a common disorder where spinal ligaments turn into bone. This study investigates the role of a protein called DLX5 in this process. The research shows that DLX5 is more active in OPLL cells and promotes bone formation when these cells are stimulated mechanically. This process involves a signaling pathway called NOTCH. By understanding how DLX5 and NOTCH contribute to OPLL, scientists hope to find new ways to treat or prevent this condition.

• 1
  DLX5 is highly expressed in OPLL cells compared to non-OPLL cells, both in vitro and in vivo.
• 2
  Mechanical stimulation increases DLX5 expression and promotes osteogenic differentiation in OPLL cells.
• 3
  NOTCH signaling regulates DLX5-mediated osteogenic differentiation in OPLL cells.