Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury—State of the Art

Peripheral nerve injuries are common in the clinical setting and may affect functionality by permanent monoplegia that could end in amputation. Electrical stimulation is an option to help recovery, in addition to exercises and locomotor training with a positive synergetic effect on nerve regeneration. These approaches could benefit from other rehabilitation techniques, such as laser and ultrasounds, as well as cell-based therapies, considering a One Health perspective.

• 1
  Non-invasive neurorehabilitation modalities could be prescribed in PNI, considering the synergetic power of FES and locomotor training as one of the best therapeutic approaches to obtain faster recovery of sensory–motor functions.
• 2
  Regenerative medicine, including stem cell transplantation (such as MSCs), are innovative therapeutic tools in the field of nerve repair that may help to revert cellular changes, reducing neural apoptosis and supporting neurogenesis
• 3
  The recovery and repair of nerve sensory–motor functions depend on several different factors, which include muscle atrophy, joint contractures, persistent lameness, a weakness that enables weight support and possible neuropathic pain.