Veterinary Medicine Research
Browse the latest research summaries in the field of veterinary medicine for spinal cord injury patients and caregivers.
Showing 1-10 of 90 results
Distinct Spatio-Temporal Extracellular Matrix Accumulation within Demyelinated Spinal Cord Lesions in Theiler’s Murine Encephalomyelitis
Brain Pathology, 2012 • January 1, 2012
The study characterized the composition and distribution of spinal cord ECM during TMEV infection to identify underlying molecular mechanisms and transcriptional changes. Microarray analysis revealed ...
KEY FINDING: Progressive accumulation of chondroitin sulfate proteoglycans, glycoproteins, and collagens occurred within demyelinated TME lesions, paralleling astrogliosis development.
Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury
J. Vet. Med. Sci., 2014 • February 21, 2014
The study investigates the therapeutic potential of canine BMSC transplantation in mice with SCI. Results showed that BMSC therapy improved hind limb function and induced Nestin-positive cells at the ...
KEY FINDING: Canine BMSC transplantation enhanced functional recovery of the hind limbs in mice with SCI.
Cytokine Concentrations in the Cerebrospinal Fluid of Great Danes with Cervical Spondylomyelopathy
J Vet Intern Med, 2014 • September 1, 2014
This study compared CSF cytokine concentrations in Great Danes with and without CSM. Lower levels of MCP-1/CCL2 were found in affected dogs, especially those with severe spinal cord compression. Highe...
KEY FINDING: Great Danes with CSM had significantly lower concentrations of MCP-1/CCL2 in their cerebrospinal fluid compared to healthy dogs.
Intrathecal Transplantation of Autologous Adherent Bone Marrow Cells Induces Functional Neurological Recovery in a Canine Model of Spinal Cord Injury
Cell Transplant, 2015 • September 1, 2015
This study investigates the safety and efficacy of autologous adherent bone marrow cell (ABMC) therapy in a canine model of spinal cord injury (SCI). The results demonstrate that intrathecal transplan...
KEY FINDING: GFP-labeled ABMCs were found in the injured spinal cord for up to 16 weeks after transplantation.
Retrospective study of partial lateral corpectomy to treat thoracic and lumbar intervertebral disc herniation in 12 cats
Journal of Feline Medicine and Surgery, 2024 • September 25, 2024
The study evaluated the safety and effectiveness of partial lateral corpectomy (PLC) in 12 cats with spinal cord compression due to intervertebral disc herniation (IVH). Outcomes showed varying degree...
KEY FINDING: PLC offers a potential treatment option for IVH to decompress the spinal cord in cats.
Penetrating airgun spinal cord injury in 23 cats (1998–2022)
Journal of Feline Medicine and Surgery, 2025 • January 1, 2025
This retrospective study evaluated 23 cats with airgun spinal cord injuries (SCIs) between 1998 and 2022. The study aimed to describe these injuries and evaluate outcomes related to surgical or conser...
KEY FINDING: Airgun spinal injuries in cats often result in severe mobility and micturition disorders.
Small Molecules Temporarily Induce Neuronal Features in Adult Canine Dermal Fibroblasts
Int. J. Mol. Sci., 2023 • October 31, 2023
This study aimed to induce neuronal features in adult canine dermal fibroblasts (ACDFs) using small molecules (SMs) and to assess the permanency of these changes, addressing the need for efficient neu...
KEY FINDING: Adult canine dermal fibroblasts (ACDFs) treated with eight small molecules (SMs) developed neuron-like morphology, including a round-shaped cell body with branching processes.
ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion
J Vet Intern Med, 2022 • May 26, 2022
This ACVIM consensus statement provides up-to-date information on the diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion (TL-IVDE). It summarizes the current literatu...
KEY FINDING: MRI, CT, CT-myelography, or myelography are reasonable modalities for diagnosing TL-IVDE, but MRI provides more detailed information about the spinal cord injury and prognosis, especially in severe cases.
Canine bone marrow peri-adipocyte cells could therapeutically benefit acute spinal cord injury through migration and secretion of hepatocyte growth factor to inflammatory milieu
Exp. Anim., 2023 • January 1, 2023
This study investigates the therapeutic potential of canine bone marrow peri-adipocyte cells (BM-PACs) for acute spinal cord injury (SCI). BM-PACs were found to secrete hepatocyte growth factor (HGF) ...
KEY FINDING: BM-PACs can secrete HGF in response to pro-inflammatory cytokines, such as TNF-α and IL-1β, and exhibit migration ability toward these cytokines.
Randomized clinical trial comparing outcomes after fentanyl or ketamine-dexmedetomidine analgesia in thoracolumbar spinal surgery in dogs
J Vet Intern Med, 2022 • September 1, 2022
This study compared the effects of fentanyl versus a ketamine-dexmedetomidine combination on recovery after spinal surgery in dogs with thoracolumbar intervertebral disc herniation. The primary outcom...
KEY FINDING: There was no significant difference in the time to recovery of ambulation between dogs treated with fentanyl and those treated with ketamine-dexmedetomidine.