Editorial: Cellular and Molecular Basis in Parasitic Diseases Control: Research Trends

Frontiers in Cell and Developmental Biology, 2022 · DOI: 10.3389/fcell.2022.897858 · Published: April 13, 2022

Simple Explanation

The editorial discusses advancements in parasitic disease control using genomic, epigenomic, proteomic, and metabolomic tools. It highlights key developments, challenges, parasite-induced immune responses, genetic and epigenetic mechanisms, and potential therapeutics. The editorial emphasizes the role of whole-genome sequencing in discovering unknown genes or variants associated with parasite phenotypes, and the challenges in genome assembly, especially for non-model species. The piece further explains how epigenomics reveals epigenetic changes, and RNA secondary structurome studies uncover thermoregulation in parasites, host-parasite interactions, and the identification of critical determinants.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Editorial

Key Findings

1
High-quality genome assembly of Moniezia expansa reveals potential target molecules for treating parasitic diseases through the identification of specific fatty acid metabolism and reproductive stem cell regulatory networks.
2
Comparative epigenomic analysis in Trichinella species helps decipher environmental effects on differential adaptation and parasitism.
3
RNA secondary structurome study reveals distinct thermoregulation in Plasmodium falciparum, providing insights into the molecular mechanism of parasite virulence and development.

Research Summary

The editorial provides an overview of the recent advancements in parasitic disease control by utilizing novel tools and methodologies developed in genomic, epigenomic, proteomics, and metabolomics research. It highlights the importance of whole-genome sequencing, epigenomic analysis, and RNA secondary structurome studies in understanding parasite biology and host-parasite interactions. The editorial also emphasizes the significance of identifying critical determinants of host-parasite interactions to develop novel molecular targets for controlling parasitic diseases.

Practical Implications

Drug Development

Identifying parasite-specific molecules and regulatory networks can lead to the development of targeted therapies.

Improved Diagnostics

Understanding the molecular mechanisms of parasite virulence and development can aid in creating better diagnostic tools.

Preventive Strategies

Insights into host-parasite interactions can inform the development of strategies to disrupt parasite transmission and infection.

Study Limitations

1
The editorial nature of the piece may limit the depth of analysis for individual studies.
2
The research is focused on molecular and cellular aspects, potentially overlooking broader ecological or social determinants of parasitic diseases.
3
The findings discussed are based on specific parasites and hosts, and may not be generalizable to all parasitic diseases.

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