Effects of forelimb amputation and denervation on protein synthesis in spinal cord ganglia of the newt

This study investigates how forelimb amputation and denervation affect protein synthesis in the nerve ganglia of newts, which are known for their ability to regenerate limbs. The research shows that amputation significantly increases protein synthesis in these ganglia, suggesting a link between nerve activity and limb regeneration. The study also identifies a group of proteins that are more prominently expressed after amputation, potentially playing a crucial role in the regeneration process.

• 1
  Forelimb amputation in newts leads to a fourfold increase in protein synthesis in the brachial nerve ganglia compared to control animals.
• 2
  Denervation without amputation nearly doubles the level of protein synthesis in the nerve ganglia compared to controls.
• 3
  A group of basic proteins ranging in Mr from 15,000 to 31,000 are prominently expressed in experimental ganglia, potentially important for forelimb regeneration.