Biochemistry Research

KEY FINDING: Myostatin (1 µg/ml) reduced the expression of miR-1 and miR-133a at 1 day post-differentiation induction but not at 3 days.

KEY FINDING: Several compounds were identified that inhibit PTPs activity in vitro with micromolar potency.

KEY FINDING: Alginate implants significantly reduced injury-induced demyelination of the contralateral white matter in the chronic state after SCI.

KEY FINDING: Histone acetylation influences neural plasticity, synaptogenesis, and synaptic plasticity, impacting tissue remodeling post-SCI. Specifically, H4 acetylation levels are time-related and affect glial fibrillary acidic protein levels.

KEY FINDING: CSPGs and HSPGs have opposite effects on axonal behavior, with CSPGs often acting as repulsive guidance molecules and HSPGs as attractive signals.

KEY FINDING: mChABC is secreted robustly from mammalian cells without altering its functional activity compared to bChABC, maintaining optimal activity on chondroitin sulfate-A at pH 8.0 and 37°C.

KEY FINDING: Rats treated with GSH showed statistically significant improvement in locomotor function based on the BBB scale compared to the saline solution group.

KEY FINDING: PAD3 expression increases with development and is further upregulated after spinal cord injury, particularly at stages when regeneration is less effective.

KEY FINDING: SCI produced a significant decrease in the level of Flot-2 at 2 days post-injury (DPI) that increased until 28 DPI.

KEY FINDING: Valacyclovir and acyclovir are deaminated by cypin, meaning cypin breaks them down.