Enhancing m6A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

Spinal cord injuries often disrupt the corticospinal tract, which is important for motor function. While some regeneration occurs naturally, the mechanisms aren't fully understood. This study focuses on m6A modifications, a common form of epigenetic RNA regulation, and its potential role in corticospinal tract regeneration after spinal cord injury. The research identifies METTL14 and its role in regulating TRIB2 expression, which activates a pathway promoting regeneration. A drug, syringin, is also shown to stabilize METTL14 and improve recovery.

• 1
  METTL14 expression in the locomotor cortex increases after spinal cord injury, along with elevated m6A levels.
• 2
  Knocking down Mettl14 hinders corticospinal tract regeneration and neurological recovery after spinal cord injury.
• 3
  Syringin, a stabilizer of METTL14, promotes corticospinal tract regeneration and facilitates neurological recovery.