Exploring the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking

This study explores how Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, may help treat spinal cord injury (SCI). It uses network pharmacology and molecular docking to understand how the decoction works. The researchers identified active compounds in BYHWD and their target genes. They then looked at how these targets interact with genes related to SCI to find common targets. Molecular docking was used to see how well the main compounds in BYHWD could bind to the key target proteins. The study aims to provide a better understanding of how BYHWD works to treat SCI.

• 1
  The study identified 109 active compounds and 5440 prediction targets from Buyang Huanwu Decoction, with 98 active components and 49 related prediction targets being strongly linked to Spinal Cord Injury.
• 2
  Eight core proteins were identified, including interleukin-6, tumor protein P53, and epidermal growth factor receptor.
• 3
  The results of molecular docking demonstrated that the primary components could attach to the target protein effectively.