Expression pattern and level of ING5 protein in normal and cancer tissues

ONCOLOGY LETTERS, 2019 · DOI: 10.3892/ol.2018.9581 · Published: January 1, 2019

Simple Explanation

The study investigates the role of Inhibitor of Growth Family 5 (ING5) as a tumor suppressor. It examines how ING5 is expressed in both normal and cancerous tissues. ING5 is involved in crucial cellular processes like DNA repair and cell growth control. The research aims to understand where ING5 is located within cells and tissues. By identifying where ING5 is active, scientists hope to develop targeted therapies for cancers, particularly colorectal cancer, where ING5 seems to play a significant role.

Study Duration

Between 2008 and 2015

Participants

986 human cancer tissues, mouse tissues

Evidence Level

Not specified

Key Findings

1
ING5 expression varies in different tissues, with cytoplasmic localization being more common in normal mouse and human tissues.
2
ING5 is more frequently expressed in breast, colorectal, and endometrial cancers compared to hepatocellular and pancreatic cancers.
3
Cytoplasmic ING5 expression may be closely associated with colorectal carcinogenesis, suggesting a potential target for therapy.

Research Summary

The study characterized the expression profile of ING5 protein in normal mouse and human tissues, and human cancer tissues. ING5 expression was primarily detected in the cytoplasm of normal mouse and human tissues, and human cancer tissues, with variations in different tissue types. The study suggests that ING5 expression may affect cell regeneration and be closely associated with colorectal carcinogenesis.

Practical Implications

Targeted Therapy Development

The identification of ING5 expression patterns can help in developing targeted therapies for cancers, particularly colorectal cancer.

Diagnostic Tool

ING5 expression levels could potentially serve as a diagnostic marker for certain cancers.

Understanding Cancer Mechanisms

Further research on ING5 could elucidate its role in cancer development and progression.

Study Limitations

1
Distinct sampling and fixation methods may influence the results.
2
The study focused on epithelial tumors, limiting the generalizability to other cancer types.
3
The exact mechanisms of how ING5 affects cell regeneration and colorectal carcinogenesis remain unclear.

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