Animals, 2021 · DOI: 10.3390/ani11082442 · Published: August 19, 2021
A non-invasive neurorehabilitation multimodal protocol (NRMP) may be applicable to chronic T3-L3 dogs 3 months after undergoing surgery for acute Intervertebral Disc Disease (IVDD) Hansen type I; this protocol has been shown to be safe, feasible, and potentially effective at improving ambulation in both open field score (OFS) 0 and OFS 1 dogs. Thus, the present case series study aimed to demonstrate that an NRMP could contribute to a functional treatment possibly based on synaptic and anatomic reorganization of the spinal cord. This case series clinical study intends to verify whether a neurorehabilitation multimodal protocol (NRMP) is a safe and feasible therapeutic protocol to be applied in SCI chronic dogs and to assess whether this NRMP allows a positive neurological evolution until ambulation and within a time period that is clinically acceptable.
NRMP (neurorehabilitation multimodal protocol) can be considered as a safe and feasible therapeutic approach for chronic post-surgical SCI dogs.
Employing NRMP may reduce the need for euthanasia in clinical settings for dogs with chronic SCI.
More controlled studies are needed to explore the association between NRMP, stem cell administration, and/or pharmacological management with 4-AP.