Gene and transgenics nomenclature for the laboratory axolotl – Ambystoma mexicanum

The laboratory axolotl is a valuable organism in biological research, especially for tissue regeneration studies. Standardized gene and transgenic nomenclature is essential for clear communication and collaboration among researchers using axolotls. The proposed guidelines aim to ensure uniformity in axolotl research by providing a consistent system for naming genes, proteins, and genetically modified animals, facilitating comparative studies with other organisms. These guidelines are designed to be consistent with those used for other model organisms, promoting findability, accessibility, interoperability, and reusability (FAIR principles) of axolotl research data.

• 1
  The paper proposes a set of guidelines for gene and transgenic nomenclature in the axolotl, covering species symbols, gene/mRNA/cDNA, protein naming, paralogs/orthologs, novel genes, transcript variants, non-coding transcripts, and mitochondrial genes.
• 2
  Specific recommendations are made for naming transgenic lines, including random insertions, knockout lines, and knock-in lines, incorporating information about the method of transgenesis, cassette details, and lab codes.
• 3
  The authors emphasize the importance of contacting the axolotl gene nomenclature committee when naming a gene to avoid confusion and maintain consistency within the research community.