GLP-1 Receptor Agonists: Beyond Diabetes—What the Neurosurgeon Needs to Know

GLP-1 receptor agonists (GLP-1 RAs) are medications initially used for diabetes but are now gaining popularity for weight management and other benefits. Neurosurgeons need to understand these drugs because increasing numbers of patients are using them, and they have implications for surgical procedures and various neurological conditions. These medications have shown promise in treating substance use disorders, providing neural protection and rehabilitation, and managing neurodegenerative diseases like Alzheimer's. Understanding their perioperative management is crucial for neurosurgeons. GLP-1 RAs may influence the management of conditions treated by neurosurgeons due to their potential clinical and preclinical benefits, making it important for neurosurgeons to stay informed about their use and implications.

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  GLP-1 RAs require tailored management for surgical patients, according to recent guidance from the American Society of Anesthesiologists.
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  GLP-1 RAs have demonstrated positive effects concerning substance use disorders, neural protection and rehabilitation, and neurodegenerative disorders, such as Alzheimer’s disease.
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  GLP-1 RAs can impact neurosurgical patients by affecting perioperative management, offering potential benefits in neuroprotection and rehabilitation, and influencing eligibility for neurosurgical interventions.