Glutathione effect on functional and histological recovery after spinal cord injury in rats

Clinics, 2024 · DOI: https://doi.org/10.1016/j.clinsp.2024.100359 · Published: January 1, 2024

Spinal Cord Injury Neurology Biochemistry

Simple Explanation

Spinal cord injuries involve initial damage followed by a secondary injury phase with biochemical events leading to further dysfunction and cell death. Glutathione (GSH) is crucial for protecting against oxidative stress during this secondary injury. The study evaluated the impact of GSH on functional and histological recovery in rats with spinal cord injuries. Rats treated with GSH showed improved motor function and axonal regeneration compared to control groups. The findings suggest that using glutathione in experimental spinal trauma can lead to better functional recovery and improved axonal regeneration rate, offering a potential therapeutic strategy.

Study Duration

42 days

Participants

40 Wistar rats

Evidence Level

Not specified

Key Findings

1
Rats treated with GSH showed statistically significant improvement in locomotor function based on the BBB scale compared to the saline solution group.
2
The GSH group exhibited a higher mean axonal Regeneration Index (RI) compared to the groups that received saline solution or no intervention, indicating improved axonal regeneration.
3
Histological analysis showed no statistically significant difference in tissue degeneration, hemorrhage, hyperemia, cellular infiltrate, and necrosis among the spinal cord injury groups.

Research Summary

This study investigated the effect of glutathione (GSH) on functional and histological recovery after experimental spinal cord injury in rats. Forty Wistar rats were subjected to spinal cord injury and divided into groups receiving GSH, saline solution, or no intervention. The results showed that the group treated with GSH exhibited better functional scores on the BBB scale and improved axonal regeneration compared to the control groups. These findings suggest that GSH may have a neuroprotective effect in spinal cord injury. The study concludes that using glutathione in experimental spinal trauma can lead to better functional recovery and improved axonal regeneration in Wistar rats. This highlights the potential therapeutic benefits of GSH in treating spinal cord injuries.

Practical Implications

Therapeutic Potential

Glutathione could be a potential therapeutic agent for improving functional recovery after spinal cord injury.

Neuroprotective Strategy

Using antioxidants like glutathione may protect neural tissue by mitigating secondary damage after spinal cord injuries.

Further Research

Future studies should explore the optimal dosage and timing of glutathione administration for maximizing its neuroprotective effects.

Study Limitations

1
Histological analysis of tissue degeneration involved some degree of subjectivity in scoring.
2
The study focused on Wistar rats, and results may not be directly applicable to other species or humans.
3
The evaluation of neuronal count through the axonal RI was higher in the group submitted to intervention with GSH compared to the other groups submitted to spinal cord injury.

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