GMP-compliant manufacturing of biologically active cell-derived vesicles produced by extrusion technology

Extracellular vesicles (EVs) are like natural delivery trucks for important molecules, offering a cell-free way to treat diseases. However, making enough EVs for treatments is hard. This study introduces a new method called BioDrone™, using cell-derived vesicles (CDVs) created through a special extrusion process, which allows to make lot more vesicles. These lab-made vesicles act like real ones and can be produced in large quantities following strict quality guidelines, paving the way for new anti-inflammatory and regenerative medicine treatments.

• 1
  Extrusion technology generates nanosized vesicles in far greater numbers than naturally obtained EVs.
• 2
  Umbilical cord mesenchymal stem cell (UCMSC)-derived CDVs exhibit a biological activity that is similar to UCMSCs or UCMSC-derived EVs.
• 3
  A GMP-compliant process was established to allow the production of a large number of UCMSC-CDVs in a reproducible manner.