Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer

This study investigates the role of alternative splicing events (ASEs) in bladder cancer (BLCA) bone metastasis, a critical area with limited research. The research aims to identify prognostic markers and understand the molecular mechanisms driving bone metastasis in BLCA. The researchers hypothesized that the splicing events of ITGB4 are regulated by the splicing factor JUP. This regulation may influence BLCA bone metastasis through the glycosphingolipid biosynthesis ganglio series pathway. The study uses data from the Cancer Genome Atlas (TCGA) and TCGASpliceSeq databases to construct predictive models and explore the molecular mechanisms involved in BLCA bone metastasis.

• 1
  Alternative splicing events (ASEs) are associated with the occurrence and progression of bladder cancer and have a relationship with its prognosis.
• 2
  SMOX-58,619-AP, INO80C-45,170-AP, and ITGB4-43,489-ES are significantly related to bone metastasis, splicing factors, and survival in bladder cancer patients.
• 3
  The splicing factor JUP regulates ITGB4 alternative splicing, potentially influencing BLCA bone metastasis through the glycosphingolipid biosynthesis ganglio series pathway.