Impact of exercise training on oxidative stress in individuals with a spinal cord injury

This study investigates the impact of exercise on oxidative stress in individuals with spinal cord injuries (SCI). Oxidative stress, an imbalance between antioxidants and free radicals, is linked to increased cardiovascular risk in SCI patients. The study compares oxidative stress levels between SCI and able-bodied individuals and examines the effects of functional electrical stimulation (FES) exercise on oxidative stress in SCI patients. The study found no significant differences in baseline oxidative stress levels between SCI and able-bodied individuals. However, a correlation was observed between fitness levels and oxidative stress in SCI patients, suggesting that higher fitness levels are associated with improved oxidative status. Despite the potential vascular benefits of FES exercise, the study concludes that the exercise stimulus was insufficient to alter oxidative stress levels in individuals with SCI. Further research with modified exercise protocols and higher intensities may be necessary to improve (anti)oxidative status.

• 1
  Baseline levels of oxidative stress and antioxidative capacity were similar between individuals with SCI and able-bodied subjects, suggesting a preserved (anti)oxidative status in SCI under basal conditions.
• 2
  A significant correlation was found between fitness level and oxidative stress in SCI individuals, indicating that higher fitness levels are related to a better oxidative status.
• 3
  FES exercise, both a single bout and 8 weeks of training, did not significantly alter oxidative stress or antioxidative capacity levels in individuals with SCI, suggesting the stimulus was insufficient.