Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice

Montelukast (MTK) is a drug used for asthma and allergies, but it doesn't always absorb well in the body. This study aimed to create a new way to take MTK, using a film that sticks to the inside of the mouth, to see if it could improve how much of the drug gets into the bloodstream and brain. The researchers tested the film in healthy people and in mice with a disease similar to Alzheimer's. They compared the film to the regular tablet form of MTK. They measured how much MTK was in the blood and spinal fluid to see how well it was absorbed. The MTK film showed better absorption compared to the tablet, and MTK was found in the spinal fluid of both humans and mice. This suggests the film could be a better way to deliver MTK, especially for people who have trouble swallowing or for treating brain-related conditions.

• 1
  The novel MTK film demonstrated significantly improved bioavailability compared to the marketed tablet in the clinical Phase 1a study.
• 2
  Measurable amounts of MTK present in the cerebrospinal fluid (CSF) in humans after administration of the mucoadhesive film.
• 3
  In mice, MTK was detected in serum and CSF after acute and chronic exposure in a dose-dependent manner, demonstrating Blood-Brain-Barrier (BBB) penetrance.