In vivo evaluation of microglia activation by intracranial iron overload in central pain after spinal cord injury

Central pain (CP) is a common problem after spinal cord injury (SCI). This study looks at how iron overload in the brain and activation of microglia (a type of brain cell) might play a role in CP development after SCI. Rats with SCI were given different treatments: an iron-chelating agent, minocycline (a microglia inhibitor), or a nitric oxide synthase inhibitor. The researchers then measured pain behavior, iron levels, and signs of microglia activation in the rats' brains. The study found that SCI led to iron overload in certain brain regions, which then activated microglia. This activation seems to be linked to the NF-κB signaling pathway, which can cause inflammation and nerve damage, ultimately contributing to CP.

• 1
  SCI induces intracranial iron overload, especially in the hindlimb sensory area, hippocampus, and thalamus.
• 2
  Intracranial iron overload activates microglia via the NF-κB signaling pathway.
• 3
  Treatment with an iron-chelating agent (DFX) or inhibitors of NF-κB or microglia can relieve CP resulting from SCI.