Intrathecal Baclofen Toxicity and Deep Coma in Minutes

J Spinal Cord Med, 2006 · DOI: · Published: January 1, 2006

Simple Explanation

This case report discusses a patient who experienced severe complications, including a seizure and coma, shortly after receiving intrathecal baclofen (ITB) treatment for spasticity. The patient's adverse reaction was attributed to a malfunction in the baclofen pump, leading to an overdose of the medication. The report highlights the importance of vigilance and preparedness for potential complications associated with ITB therapy, even though it is generally considered a safe treatment.

Study Duration

Not specified

Participants

One 33-year-old male

Evidence Level

Case Report

Key Findings

1
The patient developed respiratory difficulty, a generalized seizure, and coma minutes after ITB administration.
2
A malfunctioning drug pump was suspected, leading to a baclofen overdose.
3
Cerebrospinal fluid drainage was performed to remove excess baclofen, and the pump was replaced.

Research Summary

This case report describes a 33-year-old man with refractory spasticity who experienced acute intrathecal baclofen (ITB) toxicity leading to deep coma within minutes of drug administration. The patient's condition was attributed to a malfunctioning baclofen pump that caused an overdose. Immediate management included intubation, mechanical ventilation, and cerebrospinal fluid drainage to remove excess baclofen. The report emphasizes the importance of being aware of potential complications of ITB therapy, including pump malfunctions, and the need for prompt intervention to prevent life-threatening outcomes.

Practical Implications

Clinical Vigilance

Healthcare providers should be vigilant for signs of ITB toxicity, even minutes after administration.

Emergency Preparedness

Facilities administering ITB therapy should have protocols and equipment for managing potential complications, including respiratory support and CSF drainage.

Device Monitoring

Regularly monitor baclofen pumps for proper functioning and consider the possibility of malfunction in cases of unexpected adverse reactions.

Intrathecal Baclofen Toxicity and Deep Coma in Minutes

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Vigilance

Emergency Preparedness

Device Monitoring

Study Limitations

Your Feedback

Was this summary helpful?

Intrathecal Baclofen Toxicity and Deep Coma in Minutes

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Vigilance

Emergency Preparedness

Device Monitoring

Study Limitations

Your Feedback

Was this summary helpful?