Limb Regeneration in Axolotl: Is It Superhealing?

Axolotls possess a remarkable ability to regenerate multiple structures throughout their lives, including limbs, jaws, tail, spinal cord, and skin. This ability has been known for over 200 years, but the underlying mechanisms are still not fully understood. Regeneration shares similarities with development and wound healing. Understanding the axolotl's regenerative capacity could provide insights for regenerative medicine, potentially leading to therapies that promote regeneration in humans. Limb regeneration in axolotls involves a preparation phase and a redevelopment phase. The preparation phase involves wound healing processes, while the redevelopment phase mirrors embryonic development.

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  Limb regeneration is a biphasic process involving a preparation phase (similar to wound healing) and a redevelopment phase (similar to development).
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  Nerves play a critical role in limb regeneration, similar to their importance in liver regeneration, scarless fetal wound healing, and bone healing in other vertebrates.
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  Functional analysis techniques, including viral vectors, electroporation, and transgenesis, are being developed to study the role of specific genes during axolotl limb regeneration.