Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

Bone metastasis, often originating from breast and prostate cancers, poses significant treatment challenges due to the difficulty in delivering therapeutic agents specifically to the affected bone sites without harming healthy tissues. Lipid-based drug delivery systems, such as liposomes and solid lipid nanoparticles, offer a promising solution because of their biocompatibility and ability to target bone tissue more precisely, delivering drugs, genes, or other therapeutic substances effectively. The review examines the development, design, applications, and challenges of using lipid nano-transporters like liposomes, exosomes, and solid lipid nanoparticles for treating bone metastasis and promoting bone regeneration, while also considering the economic feasibility of these approaches.

• 1
  Lipid-based nanocarriers can be modified with bisphosphonates to enhance their affinity for bone, allowing for improved drug delivery to targeted areas within the bone structure.
• 2
  Exosomes, naturally derived vesicles, show potential as drug delivery systems due to their inherent ability to communicate with cells, offering advantages over synthetic nanoparticles in terms of biocompatibility and targeted delivery.
• 3
  Coating inorganic nanomaterials, like calcium phosphate, with lipids can improve their colloidal stability and dispersity, making them more effective for bone remodeling applications.