Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders: drug stability, targeting efficiency, and safety

Liposomes are tiny particles made of lipid bilayers that can carry drugs across the blood-brain barrier to treat central nervous system diseases. Liposomes can be prepared using various methods, including thin-film hydration, reverse-phase evaporation, solvent injection, detergent removal, and microfluidics. Liposomes are being studied for use in treating Alzheimer’s, Parkinson’s, Huntington’s, ALS, traumatic brain injury, spinal cord injury, and brain tumors.

• 1
  Liposomes enhance drug solubility, reduce toxicity, prolong half-life, and target specific ligands, making them effective in various fields.
• 2
  Surface modification of liposomes with molecules like transferrin, lactoferrin, and cell-penetrating peptides enables precise targeting of specific sites in the brain.
• 3
  Liposomes can be improved in terms of biocompatibility, biodegradability, and non-immunogenicity, as well as bioavailability, residence time, biodistribution, and selectivity of drugs.