microRNA-26a-5p Promotes Proliferation and Migration of Osteosarcoma Cells by Targeting HOXA5 in vitro and in vivo

This study investigates the role of miR-26a-5p in osteosarcoma cells. The researchers found that miR-26a-5p is highly expressed in osteosarcoma cell lines compared to noncancerous cells. This suggests that miR-26a-5p might be involved in the progression of osteosarcoma. The study further shows that overexpression of miR-26a-5p promotes cell proliferation and migration, but inhibits cell apoptosis. Conversely, reducing miR-26a-5p expression has the opposite effects. This indicates that miR-26a-5p promotes cell proliferation, migration, but inhibit apoptosis of U2OS. Researchers found that miR-26a-5p directly targets HOXA5 in U2OS cells. Overexpression of HOXA5 reversed the effects of miR-26a-5p on cell proliferation, migration, and apoptosis. These findings suggest that miR-26a-5p promotes proliferation and migration, but inhibits apoptosis of osteosarcoma cells by targeting HOXA5.

• 1
  miR-26a-5p is highly expressed in osteosarcoma cell lines compared to noncancerous cells, especially in U2OS cells.
• 2
  Overexpression of miR-26a-5p promotes cell proliferation, cell cycle progression, and migration, while inhibiting apoptosis in U2OS cells; conversely, downregulation of miR-26a-5p exhibits opposite effects.
• 3
  miR-26a-5p directly targets HOXA5 in U2OS cells, and overexpression of HOXA5 reverses the effects of miR-26a-5p on cell proliferation, migration, and apoptosis; knockdown of miR-26a-5p or overexpression of HOXA5 increases cell sensitivity to paclitaxel.