miR‑NPs‑RVG promote spinal cord injury repair: implications from spinal cord‑derived microvascular endothelial cells

Spinal cord injury often results in loss of motor and sensory functions. This study investigates the role of spinal cord-derived microvascular endothelial cells (SCMECs) in promoting axon growth, which is crucial for functional recovery after SCI. The researchers found that SCMECs can promote axon growth by downregulating miR-323-5p expression in neurons. They used neuron-targeting nanoparticles to regulate miR-323-5p expression in rats with spinal cord injury, aiming to improve functional recovery. The study suggests that miR-323-5p could be a potential therapeutic target for spinal cord injury repair, as SCMECs can promote axon outgrowth by downregulating its expression within neurons.

• 1
  SCMECs promote axon outgrowth in a non-contact fashion by downregulating miR-323-5p expression in neurons.
• 2
  Inhibition of miR-323-5p in vitro promotes axon growth, suggesting its potential as a therapeutic target.
• 3
  Neuron-targeted nanoparticles (miR-NPs-RVG) delivering miR-323-5p inhibitors promote axon regeneration and functional recovery in rats with spinal cord injury.