Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players

Traumatic spinal cord injury (SCI) leads to irreversible tissue loss and neuroinflammation. After the trauma, blood vessels are destroyed, and the blood-spinal cord barrier (BSCB) is compromised, leading to immune cell infiltration and a toxic environment affecting nerve regeneration. Understanding how the vascular components of the BSCB respond to injury is crucial for preventing BSCB impairment and improving spinal cord repair. This study focuses on the vascular transcriptome at 3- and 7-days post-injury (dpi) to identify potential molecular players specific to the injury. The study identified Cd9 and Mylip genes as differentially expressed at 3 and 7 dpi in a mouse contusion model. CD9 and MYLIP expression were injury-induced on vascular cells, suggesting their potential role in spinal cord repair.

• 1
  Cd9 and Mylip genes were identified as differentially expressed at 3 and 7 days post-injury (dpi) in a mouse contusion model of spinal cord injury.
• 2
  CD9 and MYLIP protein expression were injury-induced on vascular cells, specifically endothelial cells and pericytes, at the injury epicenter at 7 dpi.
• 3
  CD9 and MYLIP expressions were detected at the injury site with a caudal predominance.