Novel Approach for Efficient Recovery for Spinal Cord Injury Repair via Biofabricated Nano-Cerium Oxide Loaded PCL With Resveratrol to Improve in Vitro Biocompatibility and Autorecovery Abilities

Dose-Response: An International Journal, 2020 · DOI: 10.1177/1559325820933518 · Published: July 1, 2020

Spinal Cord Injury Pharmacology Biomedical

Simple Explanation

This study introduces a new method for spinal cord injury repair using nano CeO2 particles assembled onto poly (e-caprolactone) (PCL)/resveratrol (RVL). These nanomaterials are synthesized using a bio-compatible ionic liquid to enhance stability and biocompatibility. The biofabricated nano-cerium oxide loaded PCL with RVL preserves hydrogen peroxide and exhibits good catalytic performance. This suggests it has regenerative activity and biocompatibility suitable for spinal cord regeneration. The combination of nano-sized CeO2 particles, PCL polymer, and RVL enhances the catalytic performance, indicating a synergetic effect. This approach aims to improve the solubility, reduce toxicity, and increase biocompatibility for biomedical applications, particularly in spinal cord injury repair.

Study Duration

Not specified

Participants

Adult rats

Evidence Level

In vitro study

Key Findings

1
Nano CeO2 particles assembled onto PCL/RVL were successfully synthesized using a biocompatible ionic liquid.
2
The biofabricated nano-cerium oxide loaded PCL with RVL preserved hydrogen peroxide and exhibited good catalytic performance.
3
Cell viability assessments showed that RVL molecules loaded with CeO2-PCL polymer had higher cell viability compared to drug molecules loaded nano CeO2 alone.

Research Summary

The study successfully developed a biofabricated nano-cerium oxide loaded PCL polymer with RVL, characterizing the nanomaterial through various analytical techniques. The CeO2-PCL/RVL bionanomaterials demonstrated excellent biocompatibility without causing harm to neighboring tissues in in vitro and in vivo viability analyses. The CeO2-PCL/RVL bionanomaterials shows potential as a feasible medical application for functional recovery in spinal cord injury repair.

Practical Implications

Spinal Cord Injury Treatment

The biofabricated nanomaterial shows promise for functional recovery in spinal cord injuries.

Drug Delivery Systems

The PCL polymer serves as an efficient carrier for drug molecules, ensuring sustained release.

Biocompatible Materials

The CeO2-PCL/RVL composite enhances catalytic oxidative revival and biocompatibility, making it suitable for medical applications.

Study Limitations

1
The study primarily focuses on in vitro analysis, and further in vivo studies are needed to validate the findings.
2
The specific mechanisms of interaction between CeO2, PCL, and RVL require further investigation.
3
Long-term effects and potential toxicity of the nanomaterials need to be assessed for clinical translation.

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